Includes bibliographical references and index.

Machine generated contents note: 1. What is Lyme Disease? -- Basic Facts -- Bird's Eye View -- 2. Early History and Epidemiologic Surveillance -- What Was the Infectious Agent of Lyme Disease? -- The Spread of Lyme Disease and National Surveillance -- 3. What Are the Symptoms And Signs of Lyme Disease? -- Early Localized Stage -- Early Disseminated Stage -- Late Disseminated Stage -- Post-Treatment Lyme Disease Syndrome -- 4. What Do The Diagnostic Tests Tell Us? -- Blood Tests -- Urine-Based Tests -- Spinal Fluid and Brain Tests -- Other Tests -- Summary -- 5. The Great Divide and the Lyme Wars -- What Is the Great Divide? -- What Are the Lyme Wars? -- Concluding Comments Regarding the Great Divide and the Lyme Wars -- 6. Why Would Symptoms Persist After Antibiotic Treatment For Lyme Disease? -- Persistent Infection Hypothesis -- Residual Damage Hypothesis -- Persistent Immune Activation and Inflammation Hypothesis -- Neural Network Dysregulation Hypothesis -- The Relationship Between Immune Activation and Depression -- The Connection Between the Gut Microbiome and Mood -- Somatization, Anxiety, and Chronic Symptoms -- 7. What Are the Treatments For Lyme Disease? -- Treatment of Early Lyme Disease -- Treatment of Later-Stage Disseminated Lyme Disease -- Treatment Failures and Borrelia Persisters -- Risks and Benefits of Antibiotics -- Treatment of Post-Treatment Lyme Disease Syndrome -- Other Therapeutic Strategies -- 8. Other Tick-Borne Infections -- Common Tick-Borne Infectious Diseases -- Other Tick-Borne Infectious Diseases -- Other Vector-Transmitted Infections (Possibly by Ticks) -- Other Disorders Caused by Ticks but Not Inducing Human Infection -- 9. What Other Noninfectious Diseases Cause Lyme-Like Symptoms? -- Celiac Disease -- Chronic Fatigue Syndrome -- Chronic Heavy Metal Poisoning -- Chronic Inflammatory Demyelinating Polyneuropathy -- Fibromyalgia -- Lupus -- Major Depressive Disorder -- Malignancy (Cancer) -- Multiple Sclerosis -- Panic Disorder -- Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus -- Postural Orthostatic Tachycardia Syndrome -- Sleep Disorders -- Somatic Symptom Disorder -- Vitamin B12 Deficiency -- 10. Lyme Disease Prevention and Transmission -- Ticks -- Prevention Recommendations -- Transmission -- Lyme Disease and Pregnancy -- The Lyme Disease Vaccines -- New Developments in Prevention -- 11. Suggestions to the Patient Seeking Evaluation or Treatment -- How to Approach the Visit -- What to Bring to the Appointment -- Seeking a Second Opinion -- Tips for Navigating Online Health Information -- 12. Experience of the Patient With Chronic Symptoms -- Politically Charged Climate and Its Impact on the Physician-Patient Relationship -- Protean Nature of the Presentations of Lyme Disease -- Variability of Course: Waxing and Waning Symptoms -- Psychological Ramifications of an "Invisible" Chronic Illness -- The Fact that Lyme Disease Can Affect the Brain and Sensorium -- Uncertainty Surrounding Diagnosis, Treatment, and Prognosis -- Role of Mental Health Care and Resiliency -- Conclusion -- 13. Frequently Asked Questions -- Signs, Symptoms, and Diagnosis -- Overlap of Lyme Disease with Other Diseases -- Testing and Treatment for Lyme Disease -- Ticks -- Miscellaneous -- 14. Good News Emerging From Lyme Disease Research -- Recognition that Borrelia Persist -- Repeated Antibiotics Can Help -- Persister Borrelia Burgdorferi Spirochetes May Necessitate Different Treatment Approaches -- Recognition that Persistent Symptoms After Treatment for Lyme Disease Have Been Associated with Objective Biologic Findings -- Recognition that Lyme Disease Infection May Lead to Abnormally Active Neural Pathways -- "Omics Research" Can Help Improve Diagnostics and Clarify Pathophysiology -- Identification of a New Tick-Borne Infection Causing Symptoms Similar to Lyme Disease -- New Prevention Strategies -- Generic (Brand) Drug Names -- Glossary of Terms.