Filmmaker Marie Burke journeys inward into the spiritual world of traditional Native medicine. With a lifetime of experience in the ways of Native spirituality, Mary and Ed Louie are steadfastly committed to the practices that keep them accountable to the spirit world, their people and Mother Earth. In a twist of fate, sound recordist Don Howell is unexpectedly diagnosed with throat cancer during the filming process. He chooses to be treated with modern medicine, and for the first time ever, seeks Mary and Ed for spiritual guidance and healing. Though many healing practices and ceremonies are considered too sacred to be filmed, Mary and Ed decide to allow Don's doctoring to be recorded by the all-native crew for the purposes of teaching others.